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folic acid and nutrition & energy: what the evidence shows

葉酸 · folic acid · Last updated:

hintl editorial team / Nutrition Desk

Nutrition genre desk — research review

Research data last updated: |How this works

Key points

Multiple human studies report a positive effect.

For fatigue · 2 studies · 8,538 participants

hintl Evidence Score 79/100 (2 studies, confidence high).

Evidence at a glance

How does folic acid affect fatigue?

promising
79/100 Evidence ScoreConfidence: high2 studies1 RCT
How the 79 is built
Study design base
meta-analysis or systematic review
+40/40
RCT bonus
1 RCT
+5/15
Study count bonus
2 studies
+4/10
Participants bonus
Total 8,538 participants
+20/20
Consistency bonus
human studies agree
+10/10

Scoring method

Multiple human studies report a positive effect.

  • 2 human studies (8,538 participants total)
  • Studies point in broadly the same direction
  • Still unknown: few longer-duration studies

References

This page's evaluation is based on the following peer-reviewed studies (2). Each link goes directly to the primary source (PubMed / DOI).

  1. A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation in healthy humans, a randomized double-blind trial.randomized controlled trial (RCT) · International journal of medical sciences · 2023
  2. Daily iron supplementation for improving anaemia, iron status and health in menstruating women.meta-analysis · The Cochrane database of systematic reviews · 2016

Things to keep in mind

  • Nutrients and foods are not medicines. If you have a medical condition, are pregnant, or take medication, check with your doctor or pharmacist.

Related items

Evidence Scores are computed mechanically from the published research (PubMed / Semantic Scholar / OpenAlex): study design, participant numbers, and consistency across studies. An LLM is used only to extract study data, never to decide a score.

This is research-based information, not medical advice, and not a diagnosis. Consult a qualified professional about your own situation.

How the Evidence Score is calculated

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hintl editorial team / Nutrition Desk

Nutrition genre desk — research review

We continuously check the published research and translate the technical language into plain terms. The policy is to report a trend in the research, never a flat claim that something "works".

This article was produced by an editorial system from published research and is managed by the editor-in-responsibility (Takuya Hirata, representative of AJARA LLC).